2018 - Perinatal outcomes following IVF with use of donor versus partner sperm Pubblicato su:
Mohan Shashikant Kamatha,,Belavendra Antonisamya,Hepsy Y Selliaha,Antonio La Marcab,Sesh Kamal Sunkarac aChristian Medical College, Vellore, IndiabUniversity of Modena and Reggio Emilia, Modena, ItalycQueen’s Hospital, Barking Havering Redbridge University Hospitals NHS Trust, Essex, UK ABSTRACT This retrospective analysis of a large dataset did not demonstrate increased risk of preterm birth, low birth weight and high birthweight following donor sperm compared to partner sperm IVF. It is a matter of interest whether pregnancies with the use of donor sperm are associated with a higher risk of adverse perinatal outcomes comparedwith partner sperm. Anonymized data were obtained from the Human Fertilization & Embryology Authority. Data from 1991 to 2011 involving a total of95,787 singleton births (4523 with donor sperm and 91,264 with partner sperm) following fresh IVF/intracytoplasmic sperm injection (ICSI) were analysedto compare perinatal outcomes of preterm birth (PTB), low birthweight (LBW) and high birthweight (HBW). The risk of LBW was significantly lower (adjusted odds ratio [aOR] 0.88, 95% confidence interval [CI]: 0.79–0.99) following donor sperm versus partner sperm IVF/ICSI. There was no signifi-cant difference in the risk of PTB (aOR 0.93, 95% CI: 0.83–1.04), early PTB (aOR 0.86, 95% CI: 0.67–1.11), very LBW (aOR 0.95, 95% CI: 0.75–1.20), HBW(aOR 1.09, 95% CI: 0.98–1.21) and very HBW (aOR 1.15, 95% CI: 0.90–1.45) following donor sperm versus partner sperm IVF/ICSI. The current study didnot demonstrate an increased risk of adverse